Long-Term Relief

5-Year Durability3


Damaged or degenerated vertebral endplates are a significant cause of vertebrogenic chronic low back pain (CLBP). Modic changes on MRI are one objective biomarker for this type of low back pain. Prior data from the treatment arm of a sham-controlled, RCT showed maintenance of clinical improvements at 2 years following ablation of the basivertebral nerve (BVN). This study reports 5-year clinical outcomes.

Study Design

  • Prospective five year follow-up of the SMART US treatment arm patients 1, 2, 3
  • All 13 US treating sites participated
  • Retention rate of 85% per protocol treatment arm population (n=100) (PP = Per Protocol)
  • Mean follow-up of 6.4 years (range 5.4 to 7.8 years posttreatment)

Key Findings

Mean ODI over time
Mean VAS over time
Proportion of patients by % VAS reduction